In Vivo Pathogenicity of Actinomycetes (Nocardiopsis dassonvillei) spores on male albino rats

s: Nocardiopsis dassonvillei was isolated from the indoor air of critical areas of hospitals and its pathogenicity was evaluated in vivo. Male albino rats were injected I.P with Nocardiopsis dassonvillei spores (1×10 7 /rat ) for 2 weeks. Different changes in haematological and biochemical parameters after one and two weeks of actinomycete spores injection were assessed. Nocardiopsis infection caused RBCs count decrease and significantly decline Hb concentration compared to control group, while significant increase in WBCs, Neutrophil, Lymphocytes and Platelets were observed. Hepatotoxicity of Nocardiopsis was also investigated through severe drop in the activity of liver function markers (ALT, AST) after 2 weeks. Moreover, it induced hepatic apoptosis which is detected by caspase 3. It can be concluded that exposure to Nocardiopsis dassonvillei spores may cause haematological , biochemical disorders and heptotoxicity,